In the journey of life science exploration, animal cell laboratories are like sophisticated scientific research fortresses, supporting crucial fields such as medical breakthroughs, drug innovation, and bioproduction development. As a leading company in the industry, specializing in the production of purification equipment, Guangzhou Cleanroom Construction Co., Ltd. will take you on an in - depth exploration of the mysteries of the construction standards for animal cell laboratory projects today.
I. Site Selection and Layout: Laying a Solid Foundation for Experiments
Ideal Site Selection: Away from Noise and Pollution
Animal cell experiments have extremely strict requirements for environmental purity and tranquility. When selecting a site, it is necessary to keep away from busy traffic main roads, factories, and other sources of noise and pollution. It could be hidden in a quiet corner of the suburban area of the city or located in a well - planned scientific research park, reducing the subtle impact of external interference on experimental results and ensuring the accuracy of experimental data.
Rational Layout: Achieving Efficiency and Safety
· Clear Functional Zoning: The experimental area undertakes important tasks such as cell culture and complex experimental operations; the animal breeding area creates a comfortable "home" for experimental animals; the auxiliary area includes dressing rooms, washing rooms, storage rooms, and other logistical support spaces. Each area is independent yet collaborative, effectively avoiding the risk of cross - contamination.
· Separation of Personnel Flow, Logistics, and Animal Flow: Carefully plan the passageways for personnel, experimental items, and experimental animals, and set up exclusive channels to prevent "collisions" between different flow lines, maintaining the safety and order of the laboratory and laying a solid foundation for the smooth progress of experiments.
II. Building and Decoration: Creating a Stable and Clean Space
Solid Buildings: Protecting Experimental Safety
· Stable and Seismic - Resistant Structure: The building structure of the laboratory needs to bear the heavy loads of experimental equipment, animal breeding facilities, etc., and at the same time, it should have excellent seismic performance. In the face of natural disasters, it provides protection for experimental personnel and equipment. The rational use of reinforced concrete structures or steel structures greatly enhances the stability of the building.
· Scientific Floor Height Design: To ensure smooth air circulation indoors and meet the installation requirements of ventilation and air - conditioning systems and other equipment, the indoor clear height is generally not less than 2.6 meters, and the clear height of the equipment floor is not less than 2.2 meters, creating a spacious and comfortable working environment for experimental personnel.
Fine Decoration: Creating a Clean Environment
· Anti - Slip and Corrosion - Resistant Floors: The floors of the experimental area and the animal breeding area are made of seamless, anti - slip, and corrosion - resistant epoxy self - leveling floors. The skirting is flush with the wall or slightly indented, and the intersection of the floor and the wall is rounded with a radius of not less than 30 mm. This allows for thorough cleaning and disinfection, effectively suppressing the growth of dirt and bacteria.
· Dust - and Water - Resistant Walls and Ceilings: The walls and ceilings are made of color steel plates that are easy to clean and disinfect, corrosion - resistant, dust - free, crack - free, smooth, and waterproof. The surface coating has antistatic properties, reducing dust adsorption and always maintaining a high - cleanliness laboratory environment.
· Exquisite Door and Window Design: Laboratory doors close automatically and are equipped with observation windows and door locks. When there is a pressure requirement, the door opens towards the room with a higher pressure. The door of the buffer room is locked unidirectionally. For the main laboratory and its buffer room in high - level biosafety laboratories, air - tight doors are used. In terms of windows, according to different laboratory levels, external windows or closed observation windows are reasonably configured to ensure experimental safety and environmental stability.
III. Air - Conditioning, Ventilation, and Purification: Building a High - Quality Environmental Guarantee
Precise Temperature and Humidity Control: Caring for Cell Growth
· Appropriate Temperature and Humidity: Animal cells are extremely sensitive to temperature and humidity. The temperature in the experimental area is usually controlled at 20 - 26 °C, and the relative humidity is maintained at 40% - 70%. The temperature in the animal breeding area is adjusted according to the types of animals. For example, the temperature in the mouse breeding area is generally 22 - 25 °C, and the humidity is 40% - 60%. The air - conditioning system produced by Guangzhou Cleanroom Construction Co., Ltd. can accurately adjust the temperature and humidity, providing an ideal living environment for cells and animals.
· Independent Zoning Control: Given the differences in functional requirements of different areas, the air - conditioning system realizes independent zoning control. The temperature and humidity can be flexibly adjusted according to the needs of the experimental area, the animal breeding area, etc., avoiding mutual interference.
Efficient Ventilation and Air Exchange: Keeping the Air Fresh
· Reasonable Air Change Rate: To ensure fresh air in the laboratory and timely remove harmful gases and odors, the air change rate of the ventilation system has strict standards. The air change rate in the experimental area is not less than 15 times per hour, and the air change rate in the animal breeding area is not less than 10 - 15 times per hour. The specific value is flexibly adjusted according to factors such as the size of the laboratory, experimental content, and animal breeding density.
· Optimized Airflow Organization: The air - supply - from - the - top and air - exhaust - from - the - bottom airflow organization method is adopted. Fresh air is sent in from the top, flows through the experimental operation area, and is discharged from the bottom, effectively avoiding air - flow short - circuit and cross - contamination, ensuring that the experimental environment is always in a good state.
Multi - Stage Air Filtration: Improving Cleanliness Levels
· Efficient Filtration System: The laboratory is equipped with a three - stage air - filtration system consisting of primary, medium - efficiency, and high - efficiency filters. The filtration efficiency of the high - efficiency filter for particles with a particle size of ≥ 0.3μm reaches more than 99.97%, effectively removing dust particles, microorganisms, and other pollutants in the air, providing a reliable purification guarantee for the experimental environment. The purification equipment of Guangzhou Cleanroom Construction Co., Ltd. performs outstandingly in terms of filtration performance and can meet the needs of different cleanliness levels.
· Customized Cleanliness Levels: According to experimental needs, the cleanliness levels of animal cell laboratories are divided into Class 10,000, Class 100,000, etc. For example, the cell culture area often requires a cleanliness level of Class 10,000 to ensure the aseptic and pure environment for cell culture. Guangzhou Cleanroom Construction Co., Ltd. can customize purification solutions that meet experimental requirements for you, creating a clean space that meets standards.
IV. Electrical and Lighting: Ensuring Experimental Operation and User Experience
Stable Power Supply: Ensuring the Continuity of Experiments
· Reliable Power Source: The laboratory is equipped with a stable and reliable power supply system, providing a solid backing for the smooth operation of experimental equipment. For key equipment such as cell culture incubators and laminar flow hoods, uninterruptible power supplies (UPS) are set up to eliminate the fatal impact of sudden power outages on experiments.
· Strict Electrical Safety: Electrical lines are made of fire - resistant, moisture - resistant, and corrosion - resistant materials. All electrical equipment is well - grounded, and leakage protection devices are installed. The lines are carefully planned to avoid overload, providing comprehensive protection for the electrical safety of experimental personnel and equipment.
Comfortable Lighting: Facilitating Experimental Operations
· Precise Illumination Setting: The illumination in the experimental area is not less than 300 lux, meeting the strict requirements of experimental operations for light. The illumination in the animal breeding area is adjusted according to the types of animals. For example, the illumination in the mouse breeding area is generally 15 - 20 lux, simulating the natural light environment and protecting the animal's biological clock.
· Glare - Free Lighting Design: Glare - free lighting fixtures are selected to ensure the evenness of lighting, creating a comfortable visual environment for experimental personnel, effectively reducing eye fatigue, and improving the accuracy and efficiency of experimental operations.
V. Biosafety Protection: Strictly Guarding the Safety Line of Experiments
Professional Biosafety Cabinets: Protecting Experimental Personnel
· Precise Selection and Adaptation: According to the risk level of experimental operations, biosafety cabinets are reasonably selected. For low - risk operations such as cell culture, a Class II A2 biosafety cabinet can be selected; for animal cell experiments involving pathogens, a Class II B2 or Class III biosafety cabinet is required to build a safety barrier for experimental personnel and the experimental environment.
· Standard Installation and Maintenance: Biosafety cabinets are installed in areas far away from frequent personnel movement and large air - flow disturbances, such as room corners, and are regularly maintained and tested to ensure that their performance always meets high standards and continuously plays a safety protection role. Guangzhou Cleanroom Construction Co., Ltd. can provide professional guidance and support for the installation and maintenance of biosafety cabinets.
High - Efficiency Autoclaves: Eliminating Pollution Hazards
· Appropriate Capacity Selection: The laboratory is equipped with a sufficient number of autoclaves with appropriate capacities according to its scale and needs, which are used for the disinfection and sterilization of experimental waste, experimental equipment, etc., eliminating pollution hazards from the source.
· Strict Operation Specifications: Autoclaves are used strictly in accordance with operating procedures, and are regularly maintained and calibrated to ensure the stable operation of the equipment and the compliance of disinfection and sterilization effects, ensuring the safety of the laboratory environment.
Complete Emergency Protection Facilities: Responding to Emergencies
· Emergency Rescue Equipment: Eyewash stations and emergency shower devices are set up in prominent positions in the experimental area. In case of emergencies such as chemical reagents splashing into the eyes or large - area contact of the body with harmful chemicals, they can provide timely and effective first - aid measures for experimental personnel.
· Provision of High - Quality Protective Equipment: Complete and high - quality personal protective equipment, such as work clothes, gloves, masks, goggles, etc., is provided for experimental personnel, and professional training is carried out to ensure the correct use of protective equipment, comprehensively protecting the safety of experimental personnel.
The construction standards for animal cell laboratory projects are complex and detailed, and each link is closely related to the success or failure of experiments. With rich industry experience and excellent product quality, Guangzhou Cleanroom Construction Co., Ltd. provides one - stop professional equipment support for the construction of your animal cell laboratory. From the careful production of purification equipment to the precise customization of system solutions, we are committed to helping you build an international - standard, efficient, and safe animal cell laboratory. If you are planning an animal cell laboratory construction project, please feel free to contact us at any time. Let's work together to create a high - quality platform for life science research.